Cs. Navara et al., THE SPERM CENTROSOME DURING FERTILIZATION IN MAMMALS - IMPLICATIONS FOR FERTILITY AND REPRODUCTION, Reproduction, fertility and development, 7(4), 1995, pp. 747-754
This article reviews the recent discoveries that: (I) nearly all mamma
ls, including humans, inherit their centrosomes from their fathers; an
d (2) some sperm are ineffective in organizing the microtubules essent
ial for effecting genomic union during fertilization, leading to the s
peculation that these sperm have centrosome defects. In addition, the
molecular dissection and reconstitution of the human sperm centrosome
in vitro is presented.