DIRECT DETERMINATION OF THE ENANTIOMERIC PURITY OF (R)-(-AMINOGLUTETHIMIDE AND ITS MAIN METABOLITE())

Authors
CHILMONCZYK Z KSYCINSKA H CYBULSKI J
Citation
Z. Chilmonczyk et al., DIRECT DETERMINATION OF THE ENANTIOMERIC PURITY OF (R)-(-AMINOGLUTETHIMIDE AND ITS MAIN METABOLITE()), Archiv der pharmazie, 328(11-12), 1995, pp. 745-749
Citations number
17
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
328
Issue
11-12
Year of publication
1995
Pages
745 - 749
Database
ISI
SICI code
0365-6233(1995)328:11-12<745:DDOTEP>2.0.ZU;2-5
Abstract
Direct chiral separation of aminoglutethimide (1), an anticancer agent , and its major metabolite - acetylaminoglutethimide (2), on tris(3,5- dimethylphenyl-carbamoyl)cellulose working in the reverse-phase mode w ith the use of aqueous-methanolic mobile phases is described.