MULTIPLE GENETIC EVENTS INVOLVING RBI GENE DELETION AND AMPLIFICATIONOF CHROMOSOME-21 IN A CASE OF ACUTE LYMPHOCYTIC-LEUKEMIA

Authors
LIU Y SODERHALL S HEYMAN M GRANDER D BRONDUMNIELSEN K EINHORN S
Citation
Y. Liu et al., MULTIPLE GENETIC EVENTS INVOLVING RBI GENE DELETION AND AMPLIFICATIONOF CHROMOSOME-21 IN A CASE OF ACUTE LYMPHOCYTIC-LEUKEMIA, Genes, chromosomes & cancer, 9(1), 1994, pp. 72-75
Citations number
20
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Genes, chromosomes & cancer → ACNP
ISSN journal
10452257
Volume
9
Issue
1
Year of publication
1994
Pages
72 - 75
Database
ISI
SICI code
1045-2257(1994)9:1<72:MGEIRG>2.0.ZU;2-T
Abstract
A patient with acute lymphocytic leukemia was found to have a hyperdip loid karyotYpe, characterized by hexasomy 21 and del(7)(p15). It was s hown that the four extra copies of chromosome 21 were all derived from only one of the homologous chromosomes. Molecular analysis showed tha t the patient had a deletion of both alleles of the retinoblastoma (RB I) gene. These results suggest that multiple events, including loss of RBI gene function and amplification of a key gene(s) on chromosome 21 , have contributed to the leukemic transformation. (C) 1994 Wiley-Liss , Inc.