ELECTRONIC-TOPOLOGICAL INVESTIGATIONS OF THE RELATIONSHIP BETWEEN CHEMICAL-STRUCTURE AND AMBERGRIS ODOR

Rules for the occurence of the ambergris odor are given and discussed in terms of the electronic-topological approach developed previously. it is shown that the molecular fragments responsible for this odor pos sess fixed electronic and geometric characteristics associated with a distinct arrangement and the steric accessibility of an oxygen atom an d a group of carbon atoms. A series of 163 compounds including 82 acti ve and 81 inactive compounds was studied.