SYNTHESIS OF SUBSTITUTED PYRIDYLISOXAZOLE S AND THEIR 4,5-DIHYDRO ANALOGS - NOVEL INHIBITORS OF THROMBOCYTE AGGREGATION

Authors
DEMINA OV VRZHESHCH PV KHODONOV AA KOZLOVSKII VI VARFOLOMEEV SD
Citation
Ov. Demina et al., SYNTHESIS OF SUBSTITUTED PYRIDYLISOXAZOLE S AND THEIR 4,5-DIHYDRO ANALOGS - NOVEL INHIBITORS OF THROMBOCYTE AGGREGATION, Bioorganiceskaa himia, 21(12), 1995, pp. 933-940
Citations number
35
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
21
Issue
12
Year of publication
1995
Pages
933 - 940
Database
ISI
SICI code
0132-3423(1995)21:12<933:SOSPSA>2.0.ZU;2-O
Abstract
A number of substituted pyridylisoxazoles and their 4,5-dihydro analog s were synthesized by 1,3-dipolar cycloaddition of substituted nitrile oxides to either alkenes or alkynes. The synthesized compounds inhibi t arachidonic acid-induced aggregation of human thrombocytes at concen trations of 10(-6) to 10(-3) M. Due to low toxicity, these compounds c an be regarded as potential antithrombosis medicines.