Jf. Montebello et al., THE REIRRADIATION OF RECURRENT BRONCHOGENIC-CARCINOMA WITH EXTERNAL-BEAM IRRADIATION, American journal of clinical oncology, 16(6), 1993, pp. 482-488
Symptomatic local failure following thoracic irradiation for bronchoge
nic carcinoma presents a clinical challenge to the Radiation Oncologis
t. We retrospectively evaluated the efficiency of reirradiation with e
xternal beam radiation of 30 patients. The median dose of initial irra
diation was 6,000 cGy in 6 weeks. The median time following initial ir
radiation to recurrence was 12 months. The median dose of retreatment
was 3,030 cGy in 3 weeks. Of the symptomatic patients, 88% and 70% sub
jectively responded to initial irradiation and to reirradiation, respe
ctively. Retreatment toxicity included radiation esophagitis (6 patien
ts), dry desquamation (4 patients), and symptomatic radiation pneumoni
tis (1 patient). Based on this study, doses of external beam radiation
in the range of 2,000-3,000 cGy in 2 to 3 weeks appear safe and effec
tive in reirradiating recurrent bronchogenic carcinoma.