ECHINOMYCIN IN RECURRENT AND METASTATIC ENDOMETRIAL CARCINOMA - A PHASE-II TRIAL OF THE GYNECOLOGIC-ONCOLOGY-GROUP

Twenty-one evaluable patients with recurrent or metastatic endometrial carcinoma were treated with 1,500 mug/m2 of echinomycin every 3 weeks . All patients had received prior chemotherapy. There was one complete response (5%), 95% confidence interval for response is 0.9-22.7%. The major toxicity was nausea and vomiting which was moderate to severe i n 42% of patients. Myelosuppression was minimal. Echinomycin, in this dose and schedule, displays minimal activity in patients with advanced endometrial carcinoma who have had prior chemotherapy.