FORMATION OF O-6-ETHYLGUANINE IN SPERMATOGONIAL DNA OF ADULT SYRIAN GOLDEN-HAMSTER BY INTRAPERITONEAL INJECTION OF DIETHYLNITROSAMINE

Authors
KAMINO K SEILER F EMURA M THOMALE J RAJEWSKY MF MOHR U
Citation
K. Kamino et al., FORMATION OF O-6-ETHYLGUANINE IN SPERMATOGONIAL DNA OF ADULT SYRIAN GOLDEN-HAMSTER BY INTRAPERITONEAL INJECTION OF DIETHYLNITROSAMINE, Experimental and toxicologic pathology, 47(6), 1995, pp. 443-445
Citations number
10
Categorie Soggetti
Pathology,Toxicology
Journal title
Experimental and toxicologic pathology → ACNP
ISSN journal
09402993
Volume
47
Issue
6
Year of publication
1995
Pages
443 - 445
Database
ISI
SICI code
0940-2993(1995)47:6<443:FOOISD>2.0.ZU;2-V
Abstract
17-Week-old Syrian golden hamsters received a single intraperitoneal i njection of diethylnitrosamine (DEN) at a dose of 100 mg/kg body weigh t. The DNA alkylation product O-6-ethylguanine was formed in the sperm atogonia. The data demonstrate that DEN can pass the blood-testis barr ier and be metabolized in the spermatogonia to yield an alkylating der ivative or that externally activated metabolites themselves can pass t he barrier.