PREVALENCE AND PROGNOSTIC-SIGNIFICANCE OF HER2 NEU AND EPIDERMAL GROWTH-FACTOR RECEPTORS IN OVARIAN-CANCER/

We compared retrospectively the prevalence and prognostic significance of HER2/neu and epidermal growth factor receptor (ECFR) overexpressio n as detected immunohistochemically in consecutive cases of epithelial -derived ovarian cancer. HER2/neu was overexpressed in 10% (6/61) of c ases and EGFR was overexpressed in 50% (25/50). There was no significa nt association between HER2/neu or EGFR overespression and ovarian can cer stage, grade, histology or response to chemotherapy. Unlike EGFR, overexpression of HER2/neu was associated with significantly worse ove rall survival (p < 0.05), suggesting that HER2/neu may be a better pro gnostic marker than EGFR to evaluate patients with ovarian cancer.