Kc. Thresiamma et al., PROTECTIVE EFFECT OF CURCUMIN, ELLAGIC ACID AND BIXIN ON RADIATION-INDUCED LIPID-PEROXIDATION, Journal of experimental & clinical cancer research, 14(4), 1995, pp. 427-430
Serum and tissue lipid peroxides in rats were found to increase after
gamma irradiation; such an increase was found to be time and dose depe
ndent. Serum lipid peroxide level in the control animals was 2.86 nmol
/ml, which augmented to 4.2 nmole/ml 144 h after irradiation. Liver li
pid peroxide was increased from 0.25 nmole/mg protein to 5.6 nmole/mg
protein after 96 hrs, while the kidney lipid peroxide underwent a twof
old increase. Increase in serum lipid peroxide was also found to be do
se dependent. After administration of radiation dose of 14 Gy the valu
e raised to 12.2 nmole/ml. Lipid peroxides of liver and kidney showed
moderate change. Oral administration of curcumin, ellagic acid, bixin
and a-tocopherol to rats significantly reduced the increased serum and
liver lipid peroxides induced by radiation (P < 0.001). Cancer patien
ts undergoing therapeutic irradiation were found to have significant i
ncrease of serum lipid peroxide.