CHROMANONES FROM LENTINUS-CRINITUS (BASIDIOMYCETES)

The fungus Lentinus crinitus DR-5 (Basidiomycotina) produces in submer se culture the new natural products 2,2-dimethyl-6-methoxy-4-chromanon e 1, its alcohol 3 and (S)-2,2-dimethyl-3-hydroxy-6-methoxy-4-chromano ne 2. Beside these merohemiterpenes the antibiotically active hirsutan e sesquiterpenes 5 - 8 were isolated. The formation of these metabolit es displayed strong dependence from the carbon source in the medium. W hile lactose favoured the formation of the antibiotic sesquiterpene ke tones 5 and 6, they were suppressed with mannose where the hemiterpene s 1 and 4 and the hirsutane-diol 8 were the dominating metabolites.