Background: For many years there has been a widely held but largely un
substantiated belief that pain in the upper limb in decompression sick
ness (DCS) is associated with bounce diving, whereas compressed air wo
rkers, saturation divers and high altitude aviators are more susceptib
le to involvement of the lower limbs. Hypothesis: The hypothesis of co
unter current exchange of inert gas, modulated by changes in tissue te
mperature, has been evaluated as a possible mechanism to explain the r
eported distribution of limb pain in DCS. Methods: An extensive review
of over 19,000 cases of limb pain decompression illness has been unde
rtaken from case reports stored in the diving accident database at the
Institute of Naval Medicine, in the published literature, and from un
published clinical and experimental reports. Results: There was a pred
ominance of upper limb involvement in bounce divers and, in contrast t
o traditional teaching, in aviators. By contrast, the lower limbs were
more commonly involved in compressed air workers and saturation diver
s. Conclusion: Each of the occupational exposures has been discussed i
ndividually with reference to counter-current exchange and other facto
rs as potential influences on the distribution of disease. We conclude
that counter-current exchange of inert gas may be implicated in the d
istribution of limb pain in DCS.