Gray extrapolates from circuit models of psychopathology to propose ne
ural substrates for the contents of consciousness. I raise three conce
rns: (1) knowledge of synaptic arrangements may be inadequate to fully
support his model; (2) latent inhibition deficits in schizophrenia, a
focus of this and related models, are complex and deserve replication
; and (3) this conjecture omits discussion of the neuropsychological b
asis for the content of the unconscious.