THYROMIMETIC ACTION OF THE PEROXISOME PROLIFERATORS CLOFIBRATE, PERFLUOROOCTANOIC ACID, AND ACETYLSALICYLIC-ACID INCLUDES CHANGES IN MESSENGER-RNA LEVELS FOR CERTAIN GENES INVOLVED IN MITOCHONDRIAL BIOGENESIS

The effects of three peroxisome proliferators on the mRNA levels for s ome mitochondrial inner-membrane proteins in rat liver were investigat ed. Clofibrate, perfluorooctanoic acid, and acetylsalicylic acid all i ncreased the mRNA levels for the mitochondrial-encoded respiratory-cha in components cytochrome c oxidase subunit I and NADH dehydrogenase su bunit I. Mitochondrial 16S rRNA was also induced by clofibrate. The mR NA levels for the nuclear-encoded mito chondrial inner-membrane protei ns adenine nucleotide translocator and cytochrome c1 were selectively induced by the different peroxisome proliferators. Malic enzyme, which is induced by thyroid hormone, was also induced by the three peroxiso me proliferators tested. These effects are in some ways similar to tho se obtained with thyroid hormone. (C) 1996 Academic Press, Inc.