MITOCHONDRIAL NITRIC-OXIDE SYNTHASE - A UBIQUITOUS REGULATOR OF OXIDATIVE-PHOSPHORYLATION

Authors
BATES TE LOESCH A BURNSTOCK G CLARK JB
Citation
Te. Bates et al., MITOCHONDRIAL NITRIC-OXIDE SYNTHASE - A UBIQUITOUS REGULATOR OF OXIDATIVE-PHOSPHORYLATION, Biochemical and biophysical research communications, 218(1), 1996, pp. 40-44
Citations number
33
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
218
Issue
1
Year of publication
1996
Pages
40 - 44
Database
ISI
SICI code
0006-291X(1996)218:1<40:MNS-AU>2.0.ZU;2-8
Abstract
In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in mitochondria isolated from heart, skeletal mu scle, and kidney, using a monoclonal antibody directed against the end othelial form of nitric oxide synthase. The possibility that mitochond rially located nitric oxide synthase is a ubiquitous regulator of mito chondrial oxidative phosphorylation in mammalian cells is discussed. ( C) 1996 Academic Press, Inc.