T. Yoshimoto et al., ANGIOTENSIN-CONVERTING ENZYME-INHIBITOR NORMALIZES VASCULAR NATRIURETIC PEPTIDE TYPE-A RECEPTOR GENE-EXPRESSION VIA BRADYKININ-DEPENDENT MECHANISM IN HYPERTENSIVE RATS, Biochemical and biophysical research communications, 218(1), 1996, pp. 50-53
We previously demonstrated that angiotensin converting enzyme (ACE) in
hibitor normalizes the up-regulated gene expression of vascular natriu
retic peptide type A (NP-A) receptor in hypertensive rats. To elucidat
e the mechanism, we examined the effect of angiotensin ii receptor (AT
I) antagonist (TCV-116) and bradykinin receptor (B2) antagonist (Hoe 1
40) on the NP-A receptor mRNA level in the aorta of genetically hypert
ensive rats (SHR-SP/Izm) using ribonuclease protection assay. The effe
ct of ACE inhibitor on the NP-A receptor mRNA Level was completely abo
lished by a concomitant administration of Hoc 140, while TCV-116 did n
ot show any significant effect on the NP-A receptor mRNA level. These
results suggest that bradykinin plays an important role in the regulat
ion of the vascular NP-A receptor gene expression. (C) 1996 Academic P
ress, Inc.