IDENTIFICATION OF THE S-ENDO-1 ENDOTHELIAL-ASSOCIATED ANTIGEN

We have recently described a monoclonal antibody, S-Endo 1, recognizin g a molecule constitutively expressed in all types of human endothelia l cells. We showed that this protein around 118 kDa acid located at th e endothelial cell-cell junction presented sequence identity with MUC1 8 described as a tumor marker in human melanoma. The difference in ant ibodies immunoreactivity and antigen molecular weight heterogeneity ob served between various cell types strongly suggested S-Endo 1 antigen isoforms expression. (C) 1996 Academic Press, Inc.