ALCOHOL INVERSION OF 17-BETA-STEROIDS

Authors
DODGE JA LUGAR CW
Citation
Ja. Dodge et Cw. Lugar, ALCOHOL INVERSION OF 17-BETA-STEROIDS, Bioorganic & medicinal chemistry letters, 6(1), 1996, pp. 1-2
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
1
Year of publication
1996
Pages
1 - 2
Database
ISI
SICI code
0960-894X(1996)6:1<1:AIO1>2.0.ZU;2-H
Abstract
Inversion of 17 beta-steroids has been accomplished using a modified M itsunobu protocol in which 4-nitrobenzoic acid is employed as the acid ic component. Excellent yields of inverted product were obtained for a number of representative steroid families including estrogens, equile nins, and androgens. Application of this methodology to the synthesis of 17 alpha-dihydroequilenin is described.