SYNTHESIS AND BIOLOGICAL PROPERTIES OF CARBORANYLAZIRIDINES BEARING CASCADE POLYOLS

Authors
YAMAMOTO Y SADAYORI N
Citation
Y. Yamamoto et N. Sadayori, SYNTHESIS AND BIOLOGICAL PROPERTIES OF CARBORANYLAZIRIDINES BEARING CASCADE POLYOLS, Bioorganic & medicinal chemistry letters, 6(1), 1996, pp. 9-12
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
1
Year of publication
1996
Pages
9 - 12
Database
ISI
SICI code
0960-894X(1996)6:1<9:SABPOC>2.0.ZU;2-7
Abstract
1-(Carboranyl)-3-(2-methylaziridino)-2-propanols bearing cascade polyo ls, MACB(OH)(2) and MACB(OH)(4), were prepared in order to increase wa ter solubility in comparison with MACB itself. By attaching cascade po lyols as a water solubilizing element, cytotoxicity decreased and boro n uptake by cancer cells increased.