C. Papageorgiou et al., ANTI HIV-1 ACTIVITY OF A HYDROPHILIC CYCLOSPORINE DERIVATIVE WITH IMPROVED BINDING-AFFINITY TO CYCLOPHILIN-A, Bioorganic & medicinal chemistry letters, 6(1), 1996, pp. 23-26
Due to its conformation, the hydrophilic compound [(D)MeSer-3, (4-OH)M
eLeu-4] cyclosporin, 3, shows high affinity for cyclophilin A. This pr
operty, together with its lack of immunosuppression, confers 3 with ve
ry interesting anti HIV-1 activity.