RP-73163 - A BIOAVAILABLE ALKLYSULFINYL-DIPHENYLIMIDAZOLE ACAT INHIBITOR

Authors
SMITH C ASHTON MJ BUSH RC FACCHINI V HARRIS NV HART TW JORDAN R MACKENZIE R RIDDELL D
Citation
C. Smith et al., RP-73163 - A BIOAVAILABLE ALKLYSULFINYL-DIPHENYLIMIDAZOLE ACAT INHIBITOR, Bioorganic & medicinal chemistry letters, 6(1), 1996, pp. 47-50
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
1
Year of publication
1996
Pages
47 - 50
Database
ISI
SICI code
0960-894X(1996)6:1<47:R-ABAA>2.0.ZU;2-7
Abstract
RP 73163 5 the major metabolite of the ACAT inhibitor RP 76076 3 retai ns ACAT activity. This alkylsulphinyl-4,5-diphenyl-1H-imidazole has hi gher systemic bioavailability than the parent thioether, with plasma l evels of parent compound in certain species exceeding the IC50 require d for inhibition of hepatic, intestinal, artery, adrenal and macrophag e ACAT for up to twelve hours after oral dosing.