O. Ifudu et al., DISMAL REHABILITATION IN GERIATRIC INNER-CITY HEMODIALYSIS-PATIENTS, JAMA, the journal of the American Medical Association, 271(1), 1994, pp. 29-33
Objective.-To assess the extent of functional and vocational rehabilit
ation achieved by elderly inner-city patients sustained on maintenance
hemodialysis. Design.-Inception cohort study of elderly patients who
have end-stage renal disease using a modified Karnofsky rating system.
The need for a wheelchair, participation in household activities, and
effect of comorbid conditions were noted. Current status was compared
with patient's recollection of functional activity level 2 years befo
re commencing maintenance hemodialysis. Setting.-Seven outpatient, hos
pital-affiliated and private hemodialysis units in Brooklyn, NY. Patie
nts.-One hundred four patients aged 65 years or older who were receivi
ng maintenance hemodialysis for at least 6 months. Main Outcome Measur
es.-A score of 76 or greater on a modified Karnofsky scale indicated i
ndependent function at a level that permitted participation in activit
ies beyond those mandated by the hemodialysis regimen. A comorbidity s
core 6 or greater on a newly constructed index correlated with severe
debility. Employment status was also recorded. Results.-Present functi
onal activity had deteriorated to a modified Karnofsky score of 66+/-1
2.3 (+/-SD) compared with patients' recollection of a mean score of 84
+/-14.3 (P<.001) 2 years before initiation of hemodialysis. Diabetic p
atients had a lower score than nondiabetic patients. The mean comorbid
ity index of the entire study group was 7.8+/-2.9 (mean+/-SD). Within
the diabetic subset, severe debility constrained 71 patients (68%) to
limit all activity to their residence with the exception of travel to
and from their dialysis facility. By contrast, 2 years prior to commen
cing dialytic therapy, 81 diabetic patients (78%) had interests and ac
tivities that took them outside their homes (P<.001). Generalized weak
ness was the most common explanation given for the lack of outside act
ivity by nine patients (9%) who were wheelchair bound. Erythropoietin,
though regularly administered to 87 patients (84%) in the study group
, was unsuccessful in raising mean hematocrit reading above 0.28+/-0.0
5 (mean+/-SD). Conclusions.-Maintenance hemodialysis does not return i
nner-city elderly patients to their predialysis level of functioning.
Few elderly, diabetic hemodialysis patients conduct any substantive po
rtion of their lives outside their homes. For nondiabetic patients, th
e modified Karnofsky score of whites (70.4+/-11.9) and blacks (66.5+/-
15.3), though low, was equivalent (P<.4).