TIME-DEPENDENT INACTIVATION OF STEROID C-17(20)LYASE BY 17-BETA-CYCLOPROPYL ETHER-SUBSTITUTED STEROIDS

Authors
ANGELASTRO MR MARQUART AL WEINTRAUB PM GATES CA LAUGHLIN ME BLOHM TR PEET NP
Citation
Mr. Angelastro et al., TIME-DEPENDENT INACTIVATION OF STEROID C-17(20)LYASE BY 17-BETA-CYCLOPROPYL ETHER-SUBSTITUTED STEROIDS, Bioorganic & medicinal chemistry letters, 6(1), 1996, pp. 97-100
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
1
Year of publication
1996
Pages
97 - 100
Database
ISI
SICI code
0960-894X(1996)6:1<97:TIOSCB>2.0.ZU;2-B
Abstract
Androstenes bearing a cyclopropyl group attached to the C-17 beta posi tion with a heteroatom linker, designed as mechanism-based inhibitors of steroid C-17(20) lyase, were found to be potent, time-dependent inh ibitors of this enzyme.