FRONTAL TYPE DEMENTIA AND AMYOTROPHIC LAT ERAL SCLEROSIIS - 3 CLINICAL CASES WITH HMPAO TC-99M SCINTIGRAPHY

Three cases of rapid onset neuropsy dychological frontal dementia prec eded the development of sporadic amyotrophic lateral sclerosis by 12 t o 24 months HmPAO Tc-99m scintigraphy demonstrated hypoactivity in the cortex, predominantly in the frontal region. Three hypotheses are dis cussed: 1) coincidence between two degenerative diseases, Alzheimer's disease or Pick's disease and ALS; 2) and amyotrophic form of Creutzfe ld Jakob disease; 3) pre-senile dementia associated with a motoneuron disease, a clinical pathology entity recently described by Mitzuyama.