NOCTURNAL CORTISOL SECRETION IN HEALTHY-ADULTS BEFORE AND AFTER INHALATION OF BUDESONIDE

We have previously demonstrated dose-dependent nocturnal cortisol supp ression by inhaled beclomethasone and budesonide in asthmatic children . This has now been confirmed in a controlled study. Eighteen healthy adults inhaled either a single evening dose of 400 mu g budesonide or placebo or 400 mu g budesonide twice daily for 2 wk. Overnight blood s amplings for cortisol and adrenocorticotropic hormone were taken at th e beginning of the trial, at the end of the treatment period, and afte r stopping the medications. Compared with placebo, the nocturnal corti sol production was significantly reduced by 40% after a single dose of budesonide (p = 0.020) and by 37% after 2 wk of budesonide (p = 0.045 ). These data indicate that there is a single-dose rather than a cumul ative suppressive effect of inhaled corticosteroids using the specific dose and regimen studied in this protocol. The effect is not related to the underlying problem, namely asthma. The clinical relevance of th ese findings can only be elucidated in long-term follow-up studies. We believe that our findings explain the recent identification of abnorm alities in bone turnover on inhaled corticosteroids in the absence of other systemic effects. The findings emphasize the need for a cautious step-wise approach to asthma therapy.