EFFECTS OF NON-REM SLEEP ON VENTILATION AND RESPIRATORY MECHANICS IN ADULTS WITH CYSTIC-FIBROSIS

Citation
Rd. Ballard et al., EFFECTS OF NON-REM SLEEP ON VENTILATION AND RESPIRATORY MECHANICS IN ADULTS WITH CYSTIC-FIBROSIS, American journal of respiratory and critical care medicine, 153(1), 1996, pp. 266-271
Citations number
29
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
ISSN journal
1073449X
Volume
153
Issue
1
Year of publication
1996
Pages
266 - 271
Database
ISI
SICI code
1073-449X(1996)153:1<266:EONSOV>2.0.ZU;2-X
Abstract
To determine the effects of sleep upon respiratory function, five adul t patients with cystic fibrosis (CF) were monitored during sleep in a horizontal body plethysmograph. Tidal volume (VT) decreased during non -rapid-eye-movement (NREM) sleep, resulting in a NREM sleep-associated decrement in minute ventilation (VI = 11.10 +/- 0.67, 9.32 +/- 0.91, and 9.17 +/- 1.42 L during wakefulness, stage 2, and stages 3-4, respe ctively, p < 0.05). There were no NREM sleep-associated changes in res piratory frequency (f) or inspiratory time (TI), but respiratory neuro muscular output was reduced during NREM sleep P-0.1 = 3.33 +/- 0.57, 1 .79 rt 0.23, and 1.99 +/- 0.21 cm H2O during wakefulness, stage 2, and stages 3-4, respectively, p = 0.005). Upper airway resistance (Rua), lower airway resistance (Rla), and lung volume did not change in assoc iation with NREM sleep. Functional residual capacity (FRC) measurement s made using helium dilution indicated large volumes of trapped gas, l ikely a result of peripheral airways that were closed at FRC. We concl ude that in adult patients with CF, NREM sleep is associated with a de crement in VT and VI, NREM sleep does not alter airflow resistance or lung volume, and the observed reductions in VT and VI apparently resul t from a NREM sleep-associated decrease in respiratory neuromuscular o utput.