Rd. Ballard et al., EFFECTS OF NON-REM SLEEP ON VENTILATION AND RESPIRATORY MECHANICS IN ADULTS WITH CYSTIC-FIBROSIS, American journal of respiratory and critical care medicine, 153(1), 1996, pp. 266-271
Citations number
29
Categorie Soggetti
Emergency Medicine & Critical Care","Respiratory System
To determine the effects of sleep upon respiratory function, five adul
t patients with cystic fibrosis (CF) were monitored during sleep in a
horizontal body plethysmograph. Tidal volume (VT) decreased during non
-rapid-eye-movement (NREM) sleep, resulting in a NREM sleep-associated
decrement in minute ventilation (VI = 11.10 +/- 0.67, 9.32 +/- 0.91,
and 9.17 +/- 1.42 L during wakefulness, stage 2, and stages 3-4, respe
ctively, p < 0.05). There were no NREM sleep-associated changes in res
piratory frequency (f) or inspiratory time (TI), but respiratory neuro
muscular output was reduced during NREM sleep P-0.1 = 3.33 +/- 0.57, 1
.79 rt 0.23, and 1.99 +/- 0.21 cm H2O during wakefulness, stage 2, and
stages 3-4, respectively, p = 0.005). Upper airway resistance (Rua),
lower airway resistance (Rla), and lung volume did not change in assoc
iation with NREM sleep. Functional residual capacity (FRC) measurement
s made using helium dilution indicated large volumes of trapped gas, l
ikely a result of peripheral airways that were closed at FRC. We concl
ude that in adult patients with CF, NREM sleep is associated with a de
crement in VT and VI, NREM sleep does not alter airflow resistance or
lung volume, and the observed reductions in VT and VI apparently resul
t from a NREM sleep-associated decrease in respiratory neuromuscular o
utput.