ACUTE LYMPHOBLASTIC-LEUKEMIA, HYPERCALCEMIA, AND PSEUDOHYPERKALEMIA IN A DOG

A 5-month-old sexually intact male Chesapeake Bay Retriever was evalua ted for lameness of 2 weeks' duration and lymphocytosis. Acute lymphob lastic leukemia was diagnosed on the basis of results of cytologic and cytochemical evaluation of a bone marrow aspirate. Serum biochemical abnormalities included hypercalcemia and hyperkalemia. Hypercalcemia w as likely paraneoplastic; hyperkalemia was believed to be a result of release of potassium from large numbers of lymphocytes in vitro (pseud ohyperkalemia). The dog was euthanatized, and necropsy revealed infilt ration of the hepatic vasculature and sinusoids, renal parenchyma, mes enteric and peripheral lymph nodes, bone marrow, and iridial tissue wi th neoplastic cells. Unique features of this case include the young ag e of the dog and the hypercalcemia and hyperkalemia associated with ac ute lymphoblastic anemia.