T. Spanos et al., CLINICAL-EVALUATION OF DIFFERENT PREVENTI ON METHODS OF NONHEMOLYTIC TRANSFUSION REACTIONS, Transfusion clinique et biologique, 2(5), 1995, pp. 373-380
A study has been carried out on the incidence of non-hemolytic transfu
sion reaction on a group of patients suffering from thalassemia. Of th
is group, the rate of reactions per patient, based on the relationship
between the number of patients with nonhemolytic transfusion reaction
s and the total number had risen to 31.8 %. 83.7 % of the patients wit
h non-hemolytic transfusion reactions did not give a positive reaction
to lymphocytotixicity. 654 patients having, or not having shown a non
-hemolytic transfusion reaction received washed red cell concentrates
prepared extemporaneously. This process allowed the rate of reaction p
er patient to drop to 3.9 %. The transfusion of deleucocytated red cel
l concentrates by filtration, carried out on a group of 188 patients,
made the rate of reaction per patient drop to 2.8 %. As regards to rat
e reaction per patient; there is no significant difference statistical
ly between these two groups, however, it must be pointed out that the
administration of filtered red cell concentrates, by deleucocytation,
notably improves the incidence of a feverish reaction, while the admin
istration of washed red cell concentrates has an important impact on a
llergic reactions. interestingly, in solution, the washed red cell con
centrates have the added advantage of having only very small quantitie
s of free iron or vascoactive proteic derivatives. The new four bag sy
stem, now allows us to collect, separate and wash in a closed circuit.
Compared to the traditional method this system has the advantage of a
ssuring greater efficiency and security. In conclusion, for the first
time, the administration of washed red cell concentrates on patients w
ho receive regular transfusions, may represent a good procedure, combi
ned or not with deleucocytation by filtration, as to prevent the occur
rence of nonhemolytic reactions.