CLINICAL-EVALUATION OF DIFFERENT PREVENTI ON METHODS OF NONHEMOLYTIC TRANSFUSION REACTIONS

A study has been carried out on the incidence of non-hemolytic transfu sion reaction on a group of patients suffering from thalassemia. Of th is group, the rate of reactions per patient, based on the relationship between the number of patients with nonhemolytic transfusion reaction s and the total number had risen to 31.8 %. 83.7 % of the patients wit h non-hemolytic transfusion reactions did not give a positive reaction to lymphocytotixicity. 654 patients having, or not having shown a non -hemolytic transfusion reaction received washed red cell concentrates prepared extemporaneously. This process allowed the rate of reaction p er patient to drop to 3.9 %. The transfusion of deleucocytated red cel l concentrates by filtration, carried out on a group of 188 patients, made the rate of reaction per patient drop to 2.8 %. As regards to rat e reaction per patient; there is no significant difference statistical ly between these two groups, however, it must be pointed out that the administration of filtered red cell concentrates, by deleucocytation, notably improves the incidence of a feverish reaction, while the admin istration of washed red cell concentrates has an important impact on a llergic reactions. interestingly, in solution, the washed red cell con centrates have the added advantage of having only very small quantitie s of free iron or vascoactive proteic derivatives. The new four bag sy stem, now allows us to collect, separate and wash in a closed circuit. Compared to the traditional method this system has the advantage of a ssuring greater efficiency and security. In conclusion, for the first time, the administration of washed red cell concentrates on patients w ho receive regular transfusions, may represent a good procedure, combi ned or not with deleucocytation by filtration, as to prevent the occur rence of nonhemolytic reactions.