THE NEUROENDOCRINE RESPONSE TO D-FENFLURAMINE IN WOMEN WITH PREMENSTRUAL DEPRESSION

An oral d-fenfluramine neuroendocrine challenge test was carried out i n 17 women with premenstrual depression and 14 controls, twice in each subject, once in the late luteal phase when mood change was likely to be at its worst (i.e. premenstrual) and once postmenstrually. Women w eighing < 65 kg received 15 mg, the remainder 30 mg of d-fenfluramine. Although there was considerable individual variability, a substantial average prolactin response was observed in both groups but no phase, group or group X phase interaction effects were found. Oestradiol leve ls were significantly higher during the postmenstrual test but showed no relationship to prolactin response. Cortisol showed a more modest r esponse to the drug and a phase effect was found, with cortisol increa se being greater during the postmenstrual test in both groups. In cont rast to earlier findings with i.v. L-tryptophan challenge, the present study failed to show any difference in neuroendocrine response betwee n women with premenstrual depression and controls. These results sugge st that 5-hydroxy-tryptophan, receptor function is unaltered in perime nstrual mood disorder although other interpretations of the negative f indings are discussed.