Purpose: Conflicting data on the role of diet in the pathogenesis of n
ephrolithiasis prompted us to review the relevant literature regarding
the impact of diet-on urinary stone disease. Materials and Methods: M
EDLINE searches were obtained from 1966 to date using a variety of key
words, including urolithiasis, nephrolithiasis, diet, protein, carboh
ydrate, fat, calcium, oxalate, phosphate, magnesium, sulfate, citrate,
sodium, potassium, fiber, fluids, alcohol and vitamins. References ea
rlier than 1966 were obtained through bibliographies of these MEDLINE
searches. The search included in vitro and in vivo animal and human st
udies. Results: Of the extracted articles 83% addressed the issue of n
ephrolithiasis and diet, and were included in this report. All article
s were independently reviewed by each of us. The reviews were summariz
ed and compiled according to each dietary component. Conclusions: Appr
opriate dietary manipulation may be beneficial in the prevention of re
current urolithiasis in only a select group of patients.