SCREENING OF THE MACROMOLECULAR COMPONENT OF CSF FROM VARIOUS PATHOLOGIES FOR ITS INTERFERENCE WITH GABA(A) RECEPTOR FUNCTION

Authors
RAPALLINO MV CUPELLO A LEONARDI A
Citation
Mv. Rapallino et al., SCREENING OF THE MACROMOLECULAR COMPONENT OF CSF FROM VARIOUS PATHOLOGIES FOR ITS INTERFERENCE WITH GABA(A) RECEPTOR FUNCTION, Italian journal of neurological sciences, 16(9), 1995, pp. 643-646
Citations number
11
Categorie Soggetti
Neurosciences,"Clinical Neurology
Journal title
Italian journal of neurological sciences → ACNP
ISSN journal
03920461
Volume
16
Issue
9
Year of publication
1995
Pages
643 - 646
Database
ISI
SICI code
0392-0461(1995)16:9<643:SOTMCO>2.0.ZU;2-I
Abstract
Cerebrospinal fluid (CSF) samples from patients undergoing lumbar punc ture for suspected neurological diseases were fractioned into macromol ecular (MW >3000 Daltons) and small molecule components (MW <3000 Dalt ons). The macromolecular component was tested for its interference wit h GABA stimulation of Cl-36(-) accumulation in rat cerebral cortex mic rosacs. For many pathologies, no interference was apparent; an excepti on was two patients with Parkinson's disease in whom there were clear signs of stimulated GABA activity, This last result seems worthy of fu rther investigation.