DISTRIBUTION OF FELBAMATE IN BRAIN

We studied the distribution of felbamate (FBM) in rat brain using a br ain imaging scanner to analyze thaw-mount autoradiographs. After intra venous injection of [C-14]FBM in rats, the autoradiographic distributi on of isotope labeling patterns in brain was captured on x-ray film. D ensitometric differences on the x-ray film were converted into color-c ode variations representing the different concentrations of FBM in reg ions of the brain. We demonstrated that relatively uniform concentrati ons of FBM were detected throughout the brain. In all brain regions ex amined, there were no specifically high or low concentrations of FBM. We conclude that the FBM distributes uniformly.