F. Hallbook et al., NEUROTROPHINS AND THEIR RECEPTORS IN CHICKEN NEURONAL DEVELOPMENT, The International journal of developmental biology, 39(5), 1995, pp. 855-868
A review on current studies of chicken neurotrophins and their recepto
rs is given. Chicken NGF, BDNF and NT-3 have been cloned and sequences
have been used to synthesize oligonucleotides for specific localizati
on of expression during development. Also, chicken TrkA, TrkB and TrkC
have been cloned, sequenced and studied by in situ hybridization. Rec
ombinant NT-3 was applied to chicken ganglia at different developmenta
l stages to examine acquirement of responsiveness io NT-3 compared to
NGF. Phylogenetic analyses of the chicken neurotrophins and Trk recept
ors were carried out based on parsimony. Finally, some data on apoptos
is in chicken embryo sympathetic ganglia are presented.