Three cases of rhinosporidiosis in Americans who had not traveled abro
ad are reported, We believe this is the largest cluster of indigenous
cases reported in the United States. The three patients had lived in r
ural northeast Georgia all of their lives. One had a polypoid conjunct
ival lesion, and the two others had nasal polyps. In each case, the di
agnosis was made by demonstrating morphologically distinctive fungal e
lements in histopathologic sections. Clinically, rhinosporidiosis had
not been suspected.