PACLITAXEL-INDUCED RECALL SOFT-TISSUE ULCERATIONS OCCURRING AT THE SITE OF PREVIOUS SUBCUTANEOUS ADMINISTRATION OF PACLITAXEL IN LOW-DOSES

The presented case reports a rare complication of paclitaxel misuse: r ecall soft tissue injury at the site of previous subcutaneous paclitax el administration. Generally, paclitaxel extravasation causes only mil d dermatologic toxicity and ulcerations are rare. We describe the thir d case of a so-called recall dermatitis following paclitaxel chemother apy. In contrast to the previously reported cases, soft tissue damage arose at the abdominal wall at the injection sires of previously admin istered subcutaneous paclitaxel in homeopathic doses of 0.1 mg, The re call reaction continued to exacerbate after each course of systemic pa clitaxel chemotherapy and finally led to surgical treatment. The cours e of the observed skin toxicity makes it probable that the pathomechan isms involved in these recall reactions are different from those respo nsible for the limited skin toxicity observed after paclitaxel extrava sation. (C) 1996 Academic Press, Inc.