Four new briaranes, nui-inoalides A-D, (6-9) are described. They were
isolated from octocorals collected in Pohnpei and Ant atoll, Micronesi
a. The absolute stereochemistry of the known briarane juncin E (5) was
determined. Nui-inoalide A (6) and the known gemmacolides A, B, and D
(2-4) exhibit immunomodulatory activity.