Double response is a rare electrocardiographic phenomenon requiring tw
o atrioventricular conduction pathways with very different electrophys
iological properties. Double ventricular responses are the usual manif
estation: an atrial depolarisation (spontaneous or provoked, anticipat
ed or not) is followed by a first ventricular response dependant on an
accessory pathway or a rapid nodal pathway and then a second response
resulting from sufficiently delayed transmission through a nodal path
way for the ventricles to have recovered their excitability when the s
econd wave of activation reaches them. A simple curiosity when isolate
d and occurring under unusual conditions, particularly during electrop
hysiological investigation of the Wolff-Parkinson-White syndrome, the
double response may initiate symptomatic non-reentrant junctional tach
ycardia when associated with nodal duality and repeating from atria in
sinus rhythm. The functional incapacity and resistance to antiarrhyth
mic therapy may require referral for ablation of the slow pathway.