FLOW-INJECTION ANALYSIS AND LIQUID-CHROMATOGRAPHY - SURFACE-ENHANCED RAMAN-SPECTROMETRY DETECTION BY USING A WINDOWLESS FLOW CELL

Citation
Lm. Cabalin et al., FLOW-INJECTION ANALYSIS AND LIQUID-CHROMATOGRAPHY - SURFACE-ENHANCED RAMAN-SPECTROMETRY DETECTION BY USING A WINDOWLESS FLOW CELL, Analytica chimica acta, 318(2), 1996, pp. 203-210
Citations number
23
Categorie Soggetti
Chemistry Analytical
Journal title
ISSN journal
00032670
Volume
318
Issue
2
Year of publication
1996
Pages
203 - 210
Database
ISI
SICI code
0003-2670(1996)318:2<203:FAAL-S>2.0.ZU;2-T
Abstract
A windowless flow cell for detection by surface-enhanced Raman spectro metry (SERS) in two flow systems, flow-injection analysis and liquid c hromatography (LC), has been developed. Several experimental parameter s including flow-rates of silver colloid suspension and mobile phase, photon-counting integration time and bandpass of the spectrometer have been examined. The effects of those parameters on the SERS intensitie s, and the limit of detection values, of five drugs (amiloride, amiphe nazole, 2-mercaptopyridine, pemoline and triamterene) under flowing co nditions were evaluated. The maximum SERS signal was found for now-rat es of 0.075 ml min(-1) and 1.5 ml min(-1) for the mobile phase and sil ver hydrosol, respectively.