SATIETY AND CHOLECYSTOKININ

The effect of a fat and protein rich test meal of 800 kcal on subjecti ve satiety ratings and on plasma cholecystokinin (CCK) 8-S was studied in 18 acutely ill patients with anorexia nervosa, 11 former anorectic patients, who were weight recovered for at least 4 years, and in 25 h ealthy young women. Eleven normal weight patients with bulimia nervosa were studied in the same experiment. Satiety ratings were significant ly elevated in acutely ill anorectic and bulimic patients. CCK 8-S val ues were significantly stimulated by the test meal in all groups excep t from the bulimic group. Anorectic patients and weight recovered anor ectics had normal values before and after the test meal. Bulimic patie nts had significantly lower values. These data suggest that CCK 8-S is not involved in the regulation of short-term satiety in anorexia and bulimia nervosa. (C) 1994 by John Wiley & Sons, Inc.