DELAYED-HYPERSENSITIVITY AT THE INJECTION SITES OF A LOW-MOLECULAR-WEIGHT HEPARIN

We report a case of delayed hypersensitivity to a low-molecular-weight heparin. The patient presented with eczema at the site of subcutaneou s injections and allergy tests confirmed the clinical diagnosis. There were positive tests with 3 low-molecular-weight heparins and unfracti onated subcutaneous calcium heparin but negative with intravenous sodi um heparin. Although delayed hypersensitivity to low-molecular-weight heparins is rare, the possibility of cross-allergy to unfractionated h eparin could be a therapeutic problem for some patients. (C) Munksgaar d, 1996.