OPTIMIZATION BY EXPERIMENTAL-DESIGN OF THE ADSORPTIVE STRIPPING VOLTAMMETRIC PARAMETERS IN THE DETERMINATION OF CINOXACIN

The quinolone antibacterial agent cinoxacin was studied by adsorptive stripping voltammetry making use of its controlled interfacial accumul ation on a static mercury drop electrode. Measurements were obtained i n differential pulse mode and optimized by experimental design. The ch emometric approach allowed the identification of a strong interaction between pH and pulse amplitude. The dynamic linear range of calibratio n was extended from 0.4 to 9 x 10(-8) M. Analyses of cinoxacin capsule s and spiked human urine sample were carried out without the need of p revious extraction or filtration. A cleanup procedure was required to separate cinoxacin from the human plasma matrix prior to adsorptive st ripping analysis.