SKELETAL MALFORMATIONS CAUSED BY THE DH (DOMINANT HEMIMELIA) GENE IN MICE

Morphological characterization of the skeletal malformations caused by the Dh gene was carried out. Skeletal preparations from newborn mice of Dh/Dh, Dh/+ and +/+ genotypes, and adult Dh/+ mice were examined. T he Dh gene induced skeletal deformities at the axial regions from the thorax to the tail. Attachment of the ribs to the sternum was sometime s irregular, and normal segmentation of the sternum was also disrupted . Abnormal fusion of the ventral part of the rib was observed in some cases. Lumbar vertebrae were fewer in number and abnormal in shape. Al though it was rare, a curled tail was also observed due to distortion of the caudal vertebrae.