EFFECTS OF ASPIRIN AND NIFEDIPINE ALONE O R IN COMBINATION ON HEMODYNAMICS IN ANESTHETIZED DOGS

Authors
Citation
Ym. Song et al., EFFECTS OF ASPIRIN AND NIFEDIPINE ALONE O R IN COMBINATION ON HEMODYNAMICS IN ANESTHETIZED DOGS, Zhongguo yaoli xuebao, 17(1), 1996, pp. 72-74
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
ISSN journal
02539756
Volume
17
Issue
1
Year of publication
1996
Pages
72 - 74
Database
ISI
SICI code
0253-9756(1996)17:1<72:EOAANA>2.0.ZU;2-E
Abstract
AIM: To study the effects of the combination of aspirin (Asp) and nife dipine (Nif) on hemodynamics in 8 anesthetized dogs. METHODS: Tension time index (TTI), left ventricular work index (LVWI), mean arterial pr essure (MAP), and total peripheral vascular resistance (TPVR), femoral artery blood flow (FBF), ventricular systolic pressure (LVSP), maximu m of its first derivative (dp/dt(max)), left ventricular end diastolic pressure (LVEBP) and heart rate (HR) were recorded on polygraph and e lectromagnetic flowmeter. RESULTS: Asp 5, 10 mg . kg(-1), iv exerted a significant effect on the hemodynamic indices, wheras Nif 15 mu g . k g(-1), iv decreased TTI, LVWI, MAP, and TRVR, increased FBF distinctiv ely, and slightly affected LVSP, dp/dt(max), LVEDP, and HR. The effect s of Asp in combination with Nif on hemodynamics were similar to those of Nif alone, CONCLUSION: The improvement of cardiovascular function caused by Nif was not affected by the presence of Asp.