Ym. Song et al., EFFECTS OF ASPIRIN AND NIFEDIPINE ALONE O R IN COMBINATION ON HEMODYNAMICS IN ANESTHETIZED DOGS, Zhongguo yaoli xuebao, 17(1), 1996, pp. 72-74
AIM: To study the effects of the combination of aspirin (Asp) and nife
dipine (Nif) on hemodynamics in 8 anesthetized dogs. METHODS: Tension
time index (TTI), left ventricular work index (LVWI), mean arterial pr
essure (MAP), and total peripheral vascular resistance (TPVR), femoral
artery blood flow (FBF), ventricular systolic pressure (LVSP), maximu
m of its first derivative (dp/dt(max)), left ventricular end diastolic
pressure (LVEBP) and heart rate (HR) were recorded on polygraph and e
lectromagnetic flowmeter. RESULTS: Asp 5, 10 mg . kg(-1), iv exerted a
significant effect on the hemodynamic indices, wheras Nif 15 mu g . k
g(-1), iv decreased TTI, LVWI, MAP, and TRVR, increased FBF distinctiv
ely, and slightly affected LVSP, dp/dt(max), LVEDP, and HR. The effect
s of Asp in combination with Nif on hemodynamics were similar to those
of Nif alone, CONCLUSION: The improvement of cardiovascular function
caused by Nif was not affected by the presence of Asp.