USE OF TOPOLOGICAL DESCRIPTORS IN CHROMATOGRAPHIC CHIRAL SEPARATIONS

Studies of enantiomeric separations are reported, specifically the dir ect chromatographic separation of enantiomers using a chiral stationar y phase by molecular topology. The results obtained show good correlat ion equations for the capacity factor, k', and the separation factor, alpha, for different set of compounds (hydantoins, aromatic alpha-amin o acids and arylamides). Such equations may be useful for the selectio n of the optimum stationary and mobile phases for the separation of en antiomers. Further, the correlation between topological descriptors an d performance in chiral separations opens up a new approach to the des ign of chiral stationary phases.