ANALYSIS OF 2 CAPREOMYCIN-RESISTANCE DETERMINANTS FROM STREPTOMYCES-CAPREOLUS AND CHARACTERIZATION OF THE ACTION OF THEIR PRODUCTS

Authors
THIARA AS CUNDLIFFE E
Citation
As. Thiara et E. Cundliffe, ANALYSIS OF 2 CAPREOMYCIN-RESISTANCE DETERMINANTS FROM STREPTOMYCES-CAPREOLUS AND CHARACTERIZATION OF THE ACTION OF THEIR PRODUCTS, Gene, 167(1-2), 1995, pp. 121-126
Citations number
20
Categorie Soggetti
Genetics & Heredity
Journal title
Gene → ACNP
ISSN journal
03781119
Volume
167
Issue
1-2
Year of publication
1995
Pages
121 - 126
Database
ISI
SICI code
0378-1119(1995)167:1-2<121:AO2CDF>2.0.ZU;2-6
Abstract
Two genes encoding capreomycin (Cp)-modifying enzymes have been isolat ed from the producing organism Streptomyces capreolus. Cp acetyltransf erase (CAC), encoded by cac, is active against all four components of the Cp complex, whereas Cp phosphotransferase (CPH), the product of cp h, is active against Cp components IA and IIA (and also the related an tibiotic, Vm) but not against Cp IB or Cp IIB.