Comorbidity generally is measured by medical record abstraction, which
is expensive and often impractical. The aim of this study was to asse
ss the reproducibility and validity of a comorbidity questionnaire. Th
e authors developed a brief comorbidity questionnaire that included it
ems corresponding to each element of the medical record-based Charlson
index. The questionnaire was administered to 170 inpatients. Charlson
scores were abstracted from these patients' medical records. We asses
sed test-retest reliability of the questionnaire and the Charlson inde
x, the correlation between the questionnaire and the Charlson index, a
nd correlations between each comorbidity measure and indicators of hea
lth resource utilization including medication use, hospitalizations in
the past year, and hospital charges. Test-retest reliability, assesse
d with the intraclass correlation coefficient, was 0.91 for the questi
onnaire and 0.92 for the chart-based Charlson index. The Spearman corr
elation between these two measures was 0.63. The correlation between c
omorbidity measures was weaker in less educated patients. Correlations
with indicators of resource utilization were similar for the two como
rbidity instruments. The authors found that a questionnaire version of
the Charlson index is reproducible, valid, and offers practical advan
tages over medical record-based assessments.