A NEW MEMBER OF THE PROPROTEIN CONVERTASE GENE FAMILY (LPC) IS LOCATED AT A CHROMOSOME-TRANSLOCATION BREAKPOINT IN LYMPHOMAS

Authors
MEERABUX J YASPO ML ROEBROEK AJ VANDEVEN WJM LISTER TA YOUNG BD
Citation
J. Meerabux et al., A NEW MEMBER OF THE PROPROTEIN CONVERTASE GENE FAMILY (LPC) IS LOCATED AT A CHROMOSOME-TRANSLOCATION BREAKPOINT IN LYMPHOMAS, Cancer research, 56(3), 1996, pp. 448-451
Citations number
20
Categorie Soggetti
Oncology
Journal title
Cancer research → ACNP
ISSN journal
00085472
Volume
56
Issue
3
Year of publication
1996
Pages
448 - 451
Database
ISI
SICI code
0008-5472(1996)56:3<448:ANMOTP>2.0.ZU;2-Q
Abstract
A new member of the proprotein convertase gene family (LPC) has been i dentified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecula rly cloned and shown to be the result of a fusion between an intron in the 3'-untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other membe rs of the proprotein convertase family and represents a novel target f or chromosome translocation and subsequent deregulation.