GENOTOXICITY ASSAY OF CHLORAL HYDRATE AND CHLOROPICRINE

Authors
GILLER S LECURIEUX F GAUTHIER L ERB F MARZIN D
Citation
S. Giller et al., GENOTOXICITY ASSAY OF CHLORAL HYDRATE AND CHLOROPICRINE, Mutation research. Mutation research letters, 348(4), 1995, pp. 147-152
Citations number
31
Categorie Soggetti
Genetics & Heredity",Toxicology
Journal title
Mutation research. Mutation research letters → ACNP
ISSN journal
01657992
Volume
348
Issue
4
Year of publication
1995
Pages
147 - 152
Database
ISI
SICI code
0165-7992(1995)348:4<147:GAOCHA>2.0.ZU;2-9
Abstract
The chlorination by-products chloral hydrate and chloropicrine were as sayed for genotoxicity in three short-term tests. Chloropicrine was 10 0-fold more potent than chloral in inducing mutations in strain TA100 of S. typhimurium (fluctuation test) and, at variance with chloral, wa s positive in the SOS chromotest using strain PQ37 of E. coli. On the other hand, only chloral caused a significant increase in the frequenc y of micronucleated erythrocytes following in vivo exposure of the amp hibian Pleurodeles waltl newt larvae.