INTRACYTOPLASMIC SPERM INJECTION AND CONVENTIONAL IN-VITRO FERTILIZATION FOR SIBLING OOCYTES IN CASES OF UNEXPLAINED INFERTILITY AND BORDERLINE SEMEN

Purpose: In a prospective study, conventional IVF and intracytoplasmic sperm injection (ICSI) were performed on sibling oocytes of 22 patien ts with unexplained infertility (Group A) and 24 patients with borderl ine semen (Group B). Results: In Group A, there was no significant dif ference (P = 0.070) in the fertilization rate per oocyte between ICSI (63%) and conventional IVF (50.7%), however, there was total failure o f fertilization in conventional IVF in 5 of the 22 patients with IVF a nd none in ICSI. In group B, there was a significant difference (P < 0 .001) between the fertilization rate per oocyte in ICSI (59%) and conv entional IVF(27.1%). There was total failure of fertilization in II pa tients after conventional NF and none after ICSI. Conclusions: The stu dy showed that 22.7% of unexplained infertility and 45.8% of patients with borderline semen would have lost their chance of embryo transfer completely because of total failure of fertilization if ICSI was not p erformed on some oocytes in this cycle.