IMAGING AND BIODISTRIBUTION OF I-125 TYRAMINE OLIGONUCLEOTIDE IN NUDE-MICE BEARING HUMAN BREAST-TUMOR - PRELIMINARY-REPORT

Although the range of applications for antisense oligonucleotides is v ast current research concentrates mainly on virology and oncology. We have conducted in vivo and in vitro investigations of radiolabelling a nd biodistribution of a 22-mer phosphodiester oligonucleotide injected in athymic mice bearing xenograft of human mammary tumor (coculture: MCF7 and fibroblasts strain AF-11). Tumor/healthy tissue ratio of the 22-mer phosphodiester oligonucleotide fixation is high during the 24 h ours after injection instead of fast elimination.